When should the TSH level be checked after a dose of levothyroxine is started or adjusted?

In general, the TSH level should be checked approximately six weeks after a dose of levothyroxine has been started. If it is checked any sooner, it may not truly reflect the impact of the dose of levothyroxine on production of TSH by the pituitary gland. If a patient is already taking levothyroxine and the dose has been increased or decreased, the TSH level should be rechecked after at least four weeks of taking the new dose.

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